ChloroquineV1, Main, Exploration, bibRecord, 001611

History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar.

Identifieur interne : 001611 ( Main/Exploration ); précédent : 001610; suivant : 001612

History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar.

Auteurs : Valérie Andriantsoanirina [Madagascar] ; Didier Ménard [Madagascar] ; Luciano Tuseo [Madagascar] ; Rémy Durand [France]

Source :

Scandinavian Journal of Infectious Diseases [ 0036-5548 ] ; 2010.

RBID : Hal:pasteur-00741121

Abstract

Malaria remains a major health problem in Madagascar. Over past decades, the burden of malarial disease has fluctuated over time, partly in line with the successes and failures of antimalarial policy. In the 1950s and 1960s, a sharp decline in malaria transmission was observed in the central highlands due to indoor spraying with DDT and to the massive use of chloroquine by the population. Following this, the discontinuation of the 'nivaquinization' policy was followed by devastating outbreaks in the central highlands in the 1980s. Currently, the rate of in vitro chloroquine-resistant Plasmodium falciparum isolates does not exceed 5%. This figure appears disconnected from the high level of clinical treatment failure (near 40%). pfcrt mutant isolates are found in less than 1% of isolates on the Island. Conversely, pfmdr1 mutant isolates are found in more than 60% of isolates and may be responsible for the bulk of resistance to chloroquine in Madagascar. Other antimalarials remain generally effective in Madagascar. Recent clinical and in vitro data support the complete efficacy of the combination artesunate-amodiaquine in Madagascar. As such, this artemisinin combination therapy should play a central role in the control and possible elimination of P. falciparum malaria in Madagascar

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00741121

DOI: 10.3109/00365540903289670

Affiliations:

France, Madagascar

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000112
to stream Hal, to step Curation: 000112
to stream Hal, to step Checkpoint: 000186
to stream Main, to step Merge: 001613
to stream Main, to step Curation: 001611

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Malaria remains a major health problem in Madagascar. Over past decades, the burden of malarial disease has fluctuated over time, partly in line with the successes and failures of antimalarial policy. In the 1950s and 1960s, a sharp decline in malaria transmission was observed in the central highlands due to indoor spraying with DDT and to the massive use of chloroquine by the population. Following this, the discontinuation of the 'nivaquinization' policy was followed by devastating outbreaks in the central highlands in the 1980s. Currently, the rate of in vitro chloroquine-resistant Plasmodium falciparum isolates does not exceed 5%. This figure appears disconnected from the high level of clinical treatment failure (near 40%). pfcrt mutant isolates are found in less than 1% of isolates on the Island. Conversely, pfmdr1 mutant isolates are found in more than 60% of isolates and may be responsible for the bulk of resistance to chloroquine in Madagascar. Other antimalarials remain generally effective in Madagascar. Recent clinical and in vitro data support the complete efficacy of the combination artesunate-amodiaquine in Madagascar. As such, this artemisinin combination therapy should play a central role in the control and possible elimination of P. falciparum malaria in Madagascar</p>
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History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar.

History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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